BRD-K10974103_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K10974103_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC2B C-type lectin domain family 2, member B
CPVL carboxypeptidase, vitellogenic-like
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KIAA1033 KIAA1033
LAT2 linker for activation of T cells family, member 2
LPAR2 lysophosphatidic acid receptor 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPTX2 neuronal pentraxin II
PAM peptidylglycine alpha-amidating monooxygenase
PBX3 pre-B-cell leukemia homeobox 3
PPAP2B phosphatidic acid phosphatase type 2B
RBM47 RNA binding motif protein 47
RBMS1 RNA binding motif, single stranded interacting protein 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC38A1 solute carrier family 38, member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BACE2 beta-site APP-cleaving enzyme 2
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CCND1 cyclin D1
CD24 CD24 molecule
CD69 CD69 molecule
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHMP4A charged multivesicular body protein 4A
CHRDL1 chordin-like 1
COCH cochlin
CPA3 carboxypeptidase A3 (mast cell)
CSRP2 cysteine and glycine-rich protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GJA1 gap junction protein, alpha 1, 43kDa
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IGFBP3 insulin-like growth factor binding protein 3
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K6 mitogen-activated protein kinase kinase 6
MDK midkine (neurite growth-promoting factor 2)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRG1 neuregulin 1
NTS neurotensin
OLFM4 olfactomedin 4
PAIP1 poly(A) binding protein interacting protein 1
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PWP1 PWP1 homolog (S. cerevisiae)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
UBE3C ubiquitin protein ligase E3C
WDTC1 WD and tetratricopeptide repeats 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZW10 zw10 kinetochore protein