BRD-K10882151_BO2 (inhibits RAD51)_NCIH2073_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K10882151_BO2 (inhibits RAD51)_NCIH2073_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
APOA1 apolipoprotein A-I
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
FABP7 fatty acid binding protein 7, brain
FCGBP Fc fragment of IgG binding protein
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPR161 G protein-coupled receptor 161
GUSBP11 glucuronidase, beta pseudogene 11
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSR insulin receptor
KIAA0355 KIAA0355
KRT19 keratin 19, type I
MAN1A1 mannosidase, alpha, class 1A, member 1
MLPH melanophilin
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PLXNC1 plexin C1
PXDN peroxidasin
RAB27A RAB27A, member RAS oncogene family
RPL38 ribosomal protein L38
RPS5 ribosomal protein S5
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK5 serine peptidase inhibitor, Kazal type 5
STAP2 signal transducing adaptor family member 2
STC1 stanniocalcin 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TSPAN13 tetraspanin 13
VEGFA vascular endothelial growth factor A
ZG16 zymogen granule protein 16
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C3 complement component 3
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCL2 chemokine (C-C motif) ligand 2
CFI complement factor I
CHMP4A charged multivesicular body protein 4A
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
EGR3 early growth response 3
EMX2 empty spiracles homeobox 2
F3 coagulation factor III (thromboplastin, tissue factor)
FASTKD5 FAST kinase domains 5
FBXO21 F-box protein 21
GCLC glutamate-cysteine ligase, catalytic subunit
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
LGALS1 lectin, galactoside-binding, soluble, 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NPY neuropeptide Y
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP98 nucleoporin 98kDa
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLN phospholamban
PMEPA1 prostate transmembrane protein, androgen induced 1
PRSS21 protease, serine, 21 (testisin)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SCRG1 stimulator of chondrogenesis 1
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
TGFBI transforming growth factor, beta-induced, 68kDa
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)