BRD-K10705233_GW405833 hydrochloride_SKMEL1_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K10705233_GW405833 hydrochloride_SKMEL1_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AIM1 absent in melanoma 1
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE41 basic helix-loop-helix family, member e41
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CD302 CD302 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEMIP cell migration inducing protein, hyaluronan binding
CEP57 centrosomal protein 57kDa
CHN2 chimerin 2
COG7 component of oligomeric golgi complex 7
CRABP2 cellular retinoic acid binding protein 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DENND1B DENN/MADD domain containing 1B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
IPO13 importin 13
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LOXL2 lysyl oxidase-like 2
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MOXD1 monooxygenase, DBH-like 1
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PRUNE prune exopolyphosphatase
RAB25 RAB25, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFTN1 raftlin, lipid raft linker 1
RGS10 regulator of G-protein signaling 10
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SDC2 syndecan 2
SEC63 SEC63 homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOCS2 suppressor of cytokine signaling 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TF transferrin
TMEM30B transmembrane protein 30B
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABLIM1 actin binding LIM protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAALC brain and acute leukemia, cytoplasmic
BANK1 B-cell scaffold protein with ankyrin repeats 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C2CD2 C2 calcium-dependent domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCND1 cyclin D1
CCNG2 cyclin G2
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CLIP2 CAP-GLY domain containing linker protein 2
CLU clusterin
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
DYNLL1 dynein, light chain, LC8-type 1
ELOVL5 ELOVL fatty acid elongase 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETNK1 ethanolamine kinase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FXYD2 FXYD domain containing ion transport regulator 2
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0125 KIAA0125
MACF1 microtubule-actin crosslinking factor 1
MAP7 microtubule-associated protein 7
MGST3 microsomal glutathione S-transferase 3
MIPEP mitochondrial intermediate peptidase
MRPS30 mitochondrial ribosomal protein S30
ODC1 ornithine decarboxylase 1
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PIP prolactin-induced protein
PRDX1 peroxiredoxin 1
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RALGDS ral guanine nucleotide dissociation stimulator
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMSB15A thymosin beta 15a
TSC22D1 TSC22 domain family, member 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
ZBTB20 zinc finger and BTB domain containing 20