BRD-K10649245_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K10649245_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
C4BPA complement component 4 binding protein, alpha
CALR calreticulin
CD163 CD163 molecule
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CES1 carboxylesterase 1
CORO1A coronin, actin binding protein, 1A
CRABP1 cellular retinoic acid binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
ECM1 extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS2 fatty acid desaturase 2
FCGBP Fc fragment of IgG binding protein
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXYD5 FXYD domain containing ion transport regulator 5
GLRX glutaredoxin (thioltransferase)
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
ISLR immunoglobulin superfamily containing leucine-rich repeat
LOXL2 lysyl oxidase-like 2
MDK midkine (neurite growth-promoting factor 2)
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MVP major vault protein
NELL2 NEL-like 2 (chicken)
NES nestin
PDE8B phosphodiesterase 8B
PDGFRL platelet-derived growth factor receptor-like
PFKM phosphofructokinase, muscle
PGM1 phosphoglucomutase 1
PLIN2 perilipin 2
PNMA2 paraneoplastic Ma antigen 2
PON3 paraoxonase 3
PYGL phosphorylase, glycogen, liver
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSIG4 V-set and immunoglobulin domain containing 4
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EBNA1BP2 EBNA1 binding protein 2
KIF14 kinesin family member 14
KLK3 kallikrein-related peptidase 3
LUC7L3 LUC7-like 3 (S. cerevisiae)
MSMB microseminoprotein, beta-
ODC1 ornithine decarboxylase 1
PAK1IP1 PAK1 interacting protein 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TSPYL5 TSPY-like 5