BRD-K10649245_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K10649245_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
BHLHE41 basic helix-loop-helix family, member e41
CD14 CD14 molecule
CD93 CD93 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CLTC clathrin, heavy chain (Hc)
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DST dystonin
EDNRB endothelin receptor type B
EMP1 epithelial membrane protein 1
EPN2 epsin 2
FCGBP Fc fragment of IgG binding protein
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGFBP5 insulin-like growth factor binding protein 5
ITM2C integral membrane protein 2C
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
LRP4 low density lipoprotein receptor-related protein 4
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MTERF3 mitochondrial transcription termination factor 3
NLGN4X neuroligin 4, X-linked
NRCAM neuronal cell adhesion molecule
NSG1 neuron specific gene family member 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE4B phosphodiesterase 4B, cAMP-specific
PDZD2 PDZ domain containing 2
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLLP plasmolipin
PRNP prion protein
PTN pleiotrophin
RDX radixin
RGCC regulator of cell cycle
RPS5 ribosomal protein S5
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
STON1 stonin 1
SYNM synemin, intermediate filament protein
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
CCL19 chemokine (C-C motif) ligand 19
CD24 CD24 molecule
CDC45 cell division cycle 45
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL2A1 collagen, type II, alpha 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXCL13 chemokine (C-X-C motif) ligand 13
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EXOSC4 exosome component 4
FAM46A family with sequence similarity 46, member A
FYB FYN binding protein
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRX5 iroquois homeobox 5
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MRPS30 mitochondrial ribosomal protein S30
MYCBP MYC binding protein
ODC1 ornithine decarboxylase 1
PHACTR2 phosphatase and actin regulator 2
RAE1 ribonucleic acid export 1
TOX3 TOX high mobility group box family member 3