BRD-K10649245_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K10649245_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAA2 acetyl-CoA acyltransferase 2
ADGRG6 adhesion G protein-coupled receptor G6
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHMP4A charged multivesicular body protein 4A
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL3 dihydropyrimidinase-like 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5A eukaryotic translation initiation factor 5A
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LXN latexin
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
NPY1R neuropeptide Y receptor Y1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
PTPRC protein tyrosine phosphatase, receptor type, C
RAI2 retinoic acid induced 2
REEP1 receptor accessory protein 1
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TSPAN31 tetraspanin 31
WFDC1 WAP four-disulfide core domain 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BCL2L1 BCL2-like 1
CCND1 cyclin D1
CLU clusterin
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
GLDC glycine dehydrogenase (decarboxylating)
GLUL glutamate-ammonia ligase
IFITM1 interferon induced transmembrane protein 1
IL1R2 interleukin 1 receptor, type II
MCOLN1 mucolipin 1
PIH1D1 PIH1 domain containing 1
PLTP phospholipid transfer protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPRR1A small proline-rich protein 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSPAN3 tetraspanin 3