BRD-K10484463_1483-0018_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K10484463_1483-0018_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BRD2 bromodomain containing 2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLDN18 claudin 18
CLDN4 claudin 4
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IL6 interleukin 6
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
NAMPT nicotinamide phosphoribosyltransferase
OXSR1 oxidative stress responsive 1
PDLIM1 PDZ and LIM domain 1
PIR pirin (iron-binding nuclear protein)
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SFN stratifin
SFTPD surfactant protein D
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBD thrombomodulin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM2 tripartite motif containing 2
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ARMCX2 armadillo repeat containing, X-linked 2
CD200 CD200 molecule
CD24 CD24 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSC cathepsin C
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
GUSBP11 glucuronidase, beta pseudogene 11
HOXB2 homeobox B2
IGHM immunoglobulin heavy constant mu
KIAA1033 KIAA1033
MDFIC MyoD family inhibitor domain containing
MPO myeloperoxidase
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
PBX3 pre-B-cell leukemia homeobox 3
PEG3 paternally expressed 3
RAB38 RAB38, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
THY1 Thy-1 cell surface antigen
TSPAN12 tetraspanin 12
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1
ZNF91 zinc finger protein 91