BRD-K10207760_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K10207760_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD10 ankyrin repeat domain 10
BHLHE40 basic helix-loop-helix family, member e40
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CTSZ cathepsin Z
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PIP prolactin-induced protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
YPEL5 yippee-like 5 (Drosophila)
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CD24 CD24 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CHMP4A charged multivesicular body protein 4A
COL4A5 collagen, type IV, alpha 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
EVL Enah/Vasp-like
EXOSC4 exosome component 4
GJA1 gap junction protein, alpha 1, 43kDa
HPRT1 hypoxanthine phosphoribosyltransferase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
SEPP1 selenoprotein P, plasma, 1