BRD-K10114046_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K10114046_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRF5 adhesion G protein-coupled receptor F5
APOLD1 apolipoprotein L domain containing 1
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CREB1 cAMP responsive element binding protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAAM1 dishevelled associated activator of morphogenesis 1
DDIT3 DNA-damage-inducible transcript 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFT57 intraflagellar transport 57
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MPZL2 myelin protein zero-like 2
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PER1 period circadian clock 1
PHACTR2 phosphatase and actin regulator 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLVAP plasmalemma vesicle associated protein
PNKP polynucleotide kinase 3'-phosphatase
PPAP2B phosphatidic acid phosphatase type 2B
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
TMSB15A thymosin beta 15a
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
USP18 ubiquitin specific peptidase 18
VWF von Willebrand factor
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANKRD36B ankyrin repeat domain 36B
AURKA aurora kinase A
BRCA1 breast cancer 1, early onset
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CIAPIN1 cytokine induced apoptosis inhibitor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMD dystrophin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
FTH1 ferritin, heavy polypeptide 1
GOLGA8A golgin A8 family, member A
GPR137B G protein-coupled receptor 137B
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0907 KIAA0907
MEGF9 multiple EGF-like-domains 9
MID1 midline 1
NDRG3 NDRG family member 3
OLFM1 olfactomedin 1
PARP2 poly (ADP-ribose) polymerase 2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RELN reelin
RTN3 reticulon 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMX4 thioredoxin-related transmembrane protein 4
TSPYL5 TSPY-like 5
VCAN versican
WT1 Wilms tumor 1
ZBED1 zinc finger, BED-type containing 1