BRD-K10065684_DANTHRON_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K10065684_DANTHRON_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AMIGO2 adhesion molecule with Ig-like domain 2
APOC1 apolipoprotein C-I
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
C3 complement component 3
CA2 carbonic anhydrase II
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COG7 component of oligomeric golgi complex 7
CPE carboxypeptidase E
CXCR4 chemokine (C-X-C motif) receptor 4
EPCAM epithelial cell adhesion molecule
FAM69A family with sequence similarity 69, member A
FXYD3 FXYD domain containing ion transport regulator 3
GDF15 growth differentiation factor 15
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IPO13 importin 13
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KLK3 kallikrein-related peptidase 3
KRT19 keratin 19, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSLN mesothelin
MSMB microseminoprotein, beta-
MX1 MX dynamin-like GTPase 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPOX protoporphyrinogen oxidase
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGM2 transglutaminase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHIC2 cysteine-rich hydrophobic domain 2
CLTB clathrin, light chain B
CLU clusterin
COL1A1 collagen, type I, alpha 1
CRCT1 cysteine-rich C-terminal 1
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
FAM46A family with sequence similarity 46, member A
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
LAMP1 lysosomal-associated membrane protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
MFSD10 major facilitator superfamily domain containing 10
MOK MOK protein kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PRSS3 protease, serine, 3
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TRAK2 trafficking protein, kinesin binding 2
TYRP1 tyrosinase-related protein 1
ZFP36L1 ZFP36 ring finger protein-like 1