BRD-K09991945_GSK-3-inhibitor-II_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K09991945_GSK-3-inhibitor-II_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AREG amphiregulin
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL15A1 collagen, type XV, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAL galanin/GMAP prepropeptide
GPM6B glycoprotein M6B
HEATR1 HEAT repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL17RB interleukin 17 receptor B
IL32 interleukin 32
KDM5D lysine (K)-specific demethylase 5D
KIAA0922 KIAA0922
KRT16 keratin 16, type I
KRT6B keratin 6B, type II
MTCL1 microtubule crosslinking factor 1
NPR3 natriuretic peptide receptor 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPAP2B phosphatidic acid phosphatase type 2B
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SPRR1A small proline-rich protein 1A
STC2 stanniocalcin 2
TAGLN transgelin
TGFBR3 transforming growth factor, beta receptor III
TMEM97 transmembrane protein 97
TSPAN7 tetraspanin 7
TUBB2B tubulin, beta 2B class IIb
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANKMY2 ankyrin repeat and MYND domain containing 2
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BZW2 basic leucine zipper and W2 domains 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP55 centrosomal protein 55kDa
CLEC11A C-type lectin domain family 11, member A
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CYBA cytochrome b-245, alpha polypeptide
DMTF1 cyclin D binding myb-like transcription factor 1
EVI2A ecotropic viral integration site 2A
FCGBP Fc fragment of IgG binding protein
FGF13 fibroblast growth factor 13
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT2 fibronectin leucine rich transmembrane protein 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX3 glutathione peroxidase 3
GRAMD1C GRAM domain containing 1C
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
MDK midkine (neurite growth-promoting factor 2)
MSLN mesothelin
MSMB microseminoprotein, beta-
NDN necdin, melanoma antigen (MAGE) family member
NPTX2 neuronal pentraxin II
PAEP progestagen-associated endometrial protein
PCP4 Purkinje cell protein 4
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PRKCI protein kinase C, iota
QPCT glutaminyl-peptide cyclotransferase
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHB Src homology 2 domain containing adaptor protein B
SOCS2 suppressor of cytokine signaling 2
TFPI2 tissue factor pathway inhibitor 2
TM9SF3 transmembrane 9 superfamily member 3
TSPAN8 tetraspanin 8
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF185 zinc finger protein 185 (LIM domain)