BRD-K09991945_GSK-3 Inhibitor II_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTC1 actin, alpha, cardiac muscle 1
ANK2 ankyrin 2, neuronal
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CALB1 calbindin 1, 28kDa
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
FAR2 fatty acyl CoA reductase 2
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
MARS methionyl-tRNA synthetase
MDK midkine (neurite growth-promoting factor 2)
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RSL24D1 ribosomal L24 domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
THY1 Thy-1 cell surface antigen
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CD24 CD24 molecule
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FBXL12 F-box and leucine-rich repeat protein 12
HMG20B high mobility group 20B
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LIMS1 LIM and senescent cell antigen-like domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
NPY neuropeptide Y
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TACC1 transforming, acidic coiled-coil containing protein 1
TGM2 transglutaminase 2
TKT transketolase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VGLL4 vestigial-like family member 4