BRD-K09951645_dabrafenib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

77 genes differentially expressed following the BRD-K09951645_dabrafenib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANXA3 annexin A3
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
CARS cysteinyl-tRNA synthetase
CCDC92 coiled-coil domain containing 92
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DLK1 delta-like 1 homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGBP Fc fragment of IgG binding protein
GARS glycyl-tRNA synthetase
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
KLF5 Kruppel-like factor 5 (intestinal)
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
OXTR oxytocin receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RPL37A ribosomal protein L37a
SGK1 serum/glucocorticoid regulated kinase 1
SH3YL1 SH3 and SYLF domain containing 1
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TPD52L1 tumor protein D52-like 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
AMIGO2 adhesion molecule with Ig-like domain 2
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPM carboxypeptidase M
CTSC cathepsin C
DEGS1 delta(4)-desaturase, sphingolipid 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A eukaryotic translation initiation factor 5A
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC10 homeobox C10
HOXC6 homeobox C6
IL6 interleukin 6
L1CAM L1 cell adhesion molecule
LEF1 lymphoid enhancer-binding factor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLN phospholamban
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRF1 perforin 1 (pore forming protein)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TKTL1 transketolase-like 1
TMEM176B transmembrane protein 176B
TNS1 tensin 1
TUBB2A tubulin, beta 2A class IIa