BRD-K09951645_dabrafenib_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K09951645_dabrafenib_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGRN agrin
AHR aryl hydrocarbon receptor
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
BID BH3 interacting domain death agonist
BTG3 BTG family, member 3
CCR7 chemokine (C-C motif) receptor 7
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDA cytidine deaminase
CFLAR CASP8 and FADD-like apoptosis regulator
CLTB clathrin, light chain B
COL10A1 collagen, type X, alpha 1
CST3 cystatin C
CTGF connective tissue growth factor
CTSB cathepsin B
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK9 dedicator of cytokinesis 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENG endoglin
EREG epiregulin
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM171A1 family with sequence similarity 171, member A1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPX1 glutathione peroxidase 1
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HIPK2 homeodomain interacting protein kinase 2
HMGA1 high mobility group AT-hook 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER3 immediate early response 3
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP4 insulin-like growth factor binding protein 4
INPP1 inositol polyphosphate-1-phosphatase
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
JMJD1C jumonji domain containing 1C
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LDHB lactate dehydrogenase B
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LMNA lamin A/C
MBNL1 muscleblind-like splicing regulator 1
MCL1 myeloid cell leukemia 1
MEIS1 Meis homeobox 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MVP major vault protein
MYOF myoferlin
NOS3 nitric oxide synthase 3 (endothelial cell)
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
POSTN periostin, osteoblast specific factor
PRNP prion protein
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTER phosphotriesterase related
PTRF polymerase I and transcript release factor
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RGS5 regulator of G-protein signaling 5
RHOF ras homolog family member F (in filopodia)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A11 S100 calcium binding protein A11
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SQRDL sulfide quinone reductase-like (yeast)
SRGN serglycin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBD thrombomodulin
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOMM34 translocase of outer mitochondrial membrane 34
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VAMP8 vesicle-associated membrane protein 8
VCAN versican
VGLL4 vestigial-like family member 4
VNN1 vanin 1
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACAT2 acetyl-CoA acetyltransferase 2
APOC2 apolipoprotein C-II
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C5 complement component 5
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDO1 cysteine dioxygenase type 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CLU clusterin
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
ENO2 enolase 2 (gamma, neuronal)
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FZD5 frizzled class receptor 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GSE1 Gse1 coiled-coil protein
GYG2 glycogenin 2
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA2 heat shock 70kDa protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KANK1 KN motif and ankyrin repeat domains 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYZ lysozyme
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OLFM1 olfactomedin 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PENK proenkephalin
PPAP2B phosphatidic acid phosphatase type 2B
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG3A regenerating islet-derived 3 alpha
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPC25 SPC25, NDC80 kinetochore complex component
SQLE squalene epoxidase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STRA13 stimulated by retinoic acid 13
TCTN1 tectonic family member 1
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
WNT5A wingless-type MMTV integration site family, member 5A