BRD-K09951645_dabrafenib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K09951645_dabrafenib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOX2 acyl-CoA oxidase 2, branched chain
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CARS cysteinyl-tRNA synthetase
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHPT1 choline phosphotransferase 1
CLDN18 claudin 18
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ETV5 ets variant 5
GOLM1 golgi membrane protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL1R2 interleukin 1 receptor, type II
JAG1 jagged 1
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LRRC16A leucine rich repeat containing 16A
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP1B microtubule-associated protein 1B
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTA1 metastasis associated 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
SYNM synemin, intermediate filament protein
TARS threonyl-tRNA synthetase
TM9SF3 transmembrane 9 superfamily member 3
TNS1 tensin 1
TRAF5 TNF receptor-associated factor 5
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
TXNL4B thioredoxin-like 4B
XK X-linked Kx blood group
YARS tyrosyl-tRNA synthetase
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CDC45 cell division cycle 45
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CLEC11A C-type lectin domain family 11, member A
CORO1A coronin, actin binding protein, 1A
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTT1 glutathione S-transferase theta 1
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HN1 hematological and neurological expressed 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KANK1 KN motif and ankyrin repeat domains 1
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KLK11 kallikrein-related peptidase 11
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
MCM7 minichromosome maintenance complex component 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRC1 protein regulator of cytokinesis 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPA1 replication protein A1, 70kDa
S100A10 S100 calcium binding protein A10
SEPW1 selenoprotein W, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
STMN1 stathmin 1
SYNGR2 synaptogyrin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
YBX3 Y box binding protein 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)