BRD-K09951645_dabrafenib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

190 genes differentially expressed following the BRD-K09951645_dabrafenib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKAP12 A kinase (PRKA) anchor protein 12
ARMCX2 armadillo repeat containing, X-linked 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BEX4 brain expressed, X-linked 4
CALD1 caldesmon 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CEP70 centrosomal protein 70kDa
CFD complement factor D (adipsin)
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CYBA cytochrome b-245, alpha polypeptide
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DENND5A DENN/MADD domain containing 5A
DUSP1 dual specificity phosphatase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM63A family with sequence similarity 63, member A
FLNB filamin B, beta
FOLR1 folate receptor 1 (adult)
GAB2 GRB2-associated binding protein 2
GBP2 guanylate binding protein 2, interferon-inducible
GPX3 glutathione peroxidase 3
GSE1 Gse1 coiled-coil protein
H1FX H1 histone family, member X
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IRF9 interferon regulatory factor 9
ITM2A integral membrane protein 2A
JUND jun D proto-oncogene
KYNU kynureninase
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
MB myoglobin
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MSRB2 methionine sulfoxide reductase B2
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
MYO6 myosin VI
NCOA1 nuclear receptor coactivator 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PITX1 paired-like homeodomain 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNMA1 paraneoplastic Ma antigen 1
PNN pinin, desmosome associated protein
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRAF2 PRA1 domain family, member 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSENEN presenilin enhancer gamma secretase subunit
PTN pleiotrophin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
RHOC ras homolog family member C
RIN3 Ras and Rab interactor 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCAND1 SCAN domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERF2 small EDRK-rich factor 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX4 SRY (sex determining region Y)-box 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCTN1 tectonic family member 1
TMEM259 transmembrane protein 259
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TTC39A tetratricopeptide repeat domain 39A
VAT1 vesicle amine transport 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
CCNF cyclin F
CD24 CD24 molecule
CD320 CD320 molecule
CDC20 cell division cycle 20
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CORO1A coronin, actin binding protein, 1A
CST7 cystatin F (leukocystatin)
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FGFR2 fibroblast growth factor receptor 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LDHB lactate dehydrogenase B
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K3 mitogen-activated protein kinase kinase 3
NBL1 neuroblastoma 1, DAN family BMP antagonist
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP56 NOP56 ribonucleoprotein
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB4 phospholipase C, beta 4
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POPDC3 popeye domain containing 3
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB13 RAB13, member RAS oncogene family
RAN RAN, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
VIM vimentin
XPO7 exportin 7
YBX1 Y box binding protein 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)