BRD-K09854848_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K09854848_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZU1 azurocidin 1
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
CCNL1 cyclin L1
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPU centromere protein U
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CP ceruloplasmin (ferroxidase)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
ELANE elastase, neutrophil expressed
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
EZR ezrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL1R2 interleukin 1 receptor, type II
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MLF1 myeloid leukemia factor 1
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RRAD Ras-related associated with diabetes
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SCG5 secretogranin V
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SRGN serglycin
STAR steroidogenic acute regulatory protein
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM255A transmembrane protein 255A
TRIB3 tribbles pseudokinase 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ARMT1 acidic residue methyltransferase 1
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNG2 cyclin G2
CD58 CD58 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DSP desmoplakin
DST dystonin
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GFRA1 GDNF family receptor alpha 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPSM2 G-protein signaling modulator 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL1RN interleukin 1 receptor antagonist
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITGAV integrin, alpha V
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0907 KIAA0907
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LGALS1 lectin, galactoside-binding, soluble, 1
MAPT microtubule-associated protein tau
MMD monocyte to macrophage differentiation-associated
MREG melanoregulin
MRPL57 mitochondrial ribosomal protein L57
MRPS16 mitochondrial ribosomal protein S16
MUC1 mucin 1, cell surface associated
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PALLD palladin, cytoskeletal associated protein
PGAP1 post-GPI attachment to proteins 1
PI3 peptidase inhibitor 3, skin-derived
POSTN periostin, osteoblast specific factor
PRDX3 peroxiredoxin 3
PSRC1 proline/serine-rich coiled-coil 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGES prostaglandin E synthase
RAB25 RAB25, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT9 septin 9
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM106C transmembrane protein 106C
TMEM223 transmembrane protein 223
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRAK2 trafficking protein, kinesin binding 2
TRPS1 trichorhinophalangeal syndrome I
TYRP1 tyrosinase-related protein 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VCAN versican