BRD-K09854848_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-K09854848_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADM adrenomedullin
ALAS2 5'-aminolevulinate synthase 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BLNK B-cell linker
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CSRP2 cysteine and glycine-rich protein 2
CTSL cathepsin L
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EDNRB endothelin receptor type B
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HBD hemoglobin, delta
HECA headcase homolog (Drosophila)
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IRF8 interferon regulatory factor 8
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LBH limb bud and heart development
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGMN legumain
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPC surfactant protein C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TRIB1 tribbles pseudokinase 1
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
WT1 Wilms tumor 1
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACACB acetyl-CoA carboxylase beta
ACKR3 atypical chemokine receptor 3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA7 annexin A7
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX6 armadillo repeat containing, X-linked 6
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATF1 activating transcription factor 1
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BTBD3 BTB (POZ) domain containing 3
CA12 carbonic anhydrase XII
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCND1 cyclin D1
CD58 CD58 molecule
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CNOT7 CCR4-NOT transcription complex, subunit 7
COMMD8 COMM domain containing 8
COX11 COX11 cytochrome c oxidase copper chaperone
CYB561 cytochrome b561
DLD dihydrolipoamide dehydrogenase
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FKBP3 FK506 binding protein 3, 25kDa
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GBAS glioblastoma amplified sequence
GEMIN2 gem (nuclear organelle) associated protein 2
GLOD4 glyoxalase domain containing 4
HAUS4 HAUS augmin-like complex, subunit 4
HOXC6 homeobox C6
IFI44 interferon-induced protein 44
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0391 KIAA0391
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MED28 mediator complex subunit 28
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPS11 mitochondrial ribosomal protein S11
MRPS33 mitochondrial ribosomal protein S33
MTCH2 mitochondrial carrier 2
MTUS1 microtubule associated tumor suppressor 1
MUC4 mucin 4, cell surface associated
MX2 MX dynamin-like GTPase 2
MYCBP MYC binding protein
NFIB nuclear factor I/B
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OXA1L oxidase (cytochrome c) assembly 1-like
OXLD1 oxidoreductase-like domain containing 1
PBK PDZ binding kinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPA2 pyrophosphatase (inorganic) 2
PPCS phosphopantothenoylcysteine synthetase
PROM1 prominin 1
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PXMP2 peroxisomal membrane protein 2, 22kDa
RBM47 RNA binding motif protein 47
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPW1 selenoprotein W, 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
STAMBP STAM binding protein
STOML2 stomatin (EPB72)-like 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TSPYL5 TSPY-like 5
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)