BRD-K09854848_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K09854848_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY2 adenylate cyclase 2 (brain)
AEBP1 AE binding protein 1
ANGPT2 angiopoietin 2
ANGPTL2 angiopoietin-like 2
APOC1 apolipoprotein C-I
ASPN asporin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
JUNB jun B proto-oncogene
L1TD1 LINE-1 type transposase domain containing 1
LEFTY1 left-right determination factor 1
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MMP11 matrix metallopeptidase 11
MXRA5 matrix-remodelling associated 5
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
RAD51C RAD51 paralog C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
SULF1 sulfatase 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TRIM36 tripartite motif containing 36
TXNL4B thioredoxin-like 4B
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BAD BCL2-associated agonist of cell death
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CTSG cathepsin G
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GLIPR1 GLI pathogenesis-related 1
GSTP1 glutathione S-transferase pi 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB7 homeobox B7
IGFBP6 insulin-like growth factor binding protein 6
LBR lamin B receptor
MALL mal, T-cell differentiation protein-like
MBNL1 muscleblind-like splicing regulator 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
PFKP phosphofructokinase, platelet
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1A small proline-rich protein 1A
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMED3 transmembrane emp24 protein transport domain containing 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2
ZBTB18 zinc finger and BTB domain containing 18