BRD-K09638361_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K09638361_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
CAST calpastatin
CCDC109B coiled-coil domain containing 109B
CCNA1 cyclin A1
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC5A C-type lectin domain family 5, member A
CLIC4 chloride intracellular channel 4
CST7 cystatin F (leukocystatin)
DPYSL3 dihydropyrimidinase-like 3
DYNLT1 dynein, light chain, Tctex-type 1
ELANE elastase, neutrophil expressed
EZR ezrin
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL galanin/GMAP prepropeptide
GPM6B glycoprotein M6B
HEBP2 heme binding protein 2
HMG20B high mobility group 20B
IDO1 indoleamine 2,3-dioxygenase 1
INHBA inhibin, beta A
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MICALL1 MICAL-like 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
PRTN3 proteinase 3
PSCA prostate stem cell antigen
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBKS ribokinase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STK17A serine/threonine kinase 17a
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TPM4 tropomyosin 4
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA6 annexin A6
APOD apolipoprotein D
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
DLK1 delta-like 1 homolog (Drosophila)
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
HELLS helicase, lymphoid-specific
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTBP3 latent transforming growth factor beta binding protein 3
MAP2K6 mitogen-activated protein kinase kinase 6
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NREP neuronal regeneration related protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PROM1 prominin 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RHOBTB3 Rho-related BTB domain containing 3
RXRA retinoid X receptor, alpha
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN3 tetraspanin 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFDC2 WAP four-disulfide core domain 2
ZW10 zw10 kinetochore protein