BRD-K09499853_KU 0060648 trihydrochloride_LOVO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K09499853_KU 0060648 trihydrochloride_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANKRD12 ankyrin repeat domain 12
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASMTL acetylserotonin O-methyltransferase-like
ATP7A ATPase, Cu++ transporting, alpha polypeptide
CA4 carbonic anhydrase IV
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CCP110 centriolar coiled coil protein 110kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLDN10 claudin 10
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
ECHDC3 enoyl CoA hydratase domain containing 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FGFR3 fibroblast growth factor receptor 3
GAB2 GRB2-associated binding protein 2
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
MAP7 microtubule-associated protein 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MDFIC MyoD family inhibitor domain containing
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NREP neuronal regeneration related protein
OSBPL1A oxysterol binding protein-like 1A
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SNX11 sorting nexin 11
SPAG9 sperm associated antigen 9
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SST somatostatin
SULF1 sulfatase 1
TANK TRAF family member-associated NFKB activator
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TRPS1 trichorhinophalangeal syndrome I
TST thiosulfate sulfurtransferase (rhodanese)
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ATG3 autophagy related 3
C3 complement component 3
CALR calreticulin
CAPG capping protein (actin filament), gelsolin-like
CBR1 carbonyl reductase 1
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD69 CD69 molecule
CDC25A cell division cycle 25A
CLTB clathrin, light chain B
CPVL carboxypeptidase, vitellogenic-like
CSTA cystatin A (stefin A)
CTSC cathepsin C
DES desmin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP4 dual specificity phosphatase 4
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EREG epiregulin
F12 coagulation factor XII (Hageman factor)
FBLN1 fibulin 1
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GRWD1 glutamate-rich WD repeat containing 1
HEATR1 HEAT repeat containing 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL18 interleukin 18
IL33 interleukin 33
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KRT10 keratin 10, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
MGST2 microsomal glutathione S-transferase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MRPS7 mitochondrial ribosomal protein S7
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OLFM4 olfactomedin 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PERP PERP, TP53 apoptosis effector
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTS 6-pyruvoyltetrahydropterin synthase
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEPT9 septin 9
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SMAGP small cell adhesion glycoprotein
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPE small nuclear ribonucleoprotein polypeptide E
SOAT1 sterol O-acyltransferase 1
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
TCERG1 transcription elongation regulator 1
TCP1 t-complex 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE3C ubiquitin protein ligase E3C
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing