BRD-K09499853_KU 0060648 trihydrochloride_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K09499853_KU 0060648 trihydrochloride_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBXO21 F-box protein 21
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXN3 forkhead box N3
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GNS glucosamine (N-acetyl)-6-sulfatase
GSDMB gasdermin B
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA7 integrin, alpha 7
KDM3A lysine (K)-specific demethylase 3A
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NBPF10 neuroblastoma breakpoint family, member 10
NDRG1 N-myc downstream regulated 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PNRC1 proline-rich nuclear receptor coactivator 1
PRRC2C proline-rich coiled-coil 2C
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RB1CC1 RB1-inducible coiled-coil 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
ROGDI rogdi homolog (Drosophila)
RTN2 reticulon 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX2 sorting nexin 2
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SRGN serglycin
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
UBE2B ubiquitin-conjugating enzyme E2B
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX6 armadillo repeat containing, X-linked 6
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
C8ORF4 chromosome 8 open reading frame 4
CD59 CD59 molecule, complement regulatory protein
COCH cochlin
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
ICAM2 intercellular adhesion molecule 2
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
INTS3 integrator complex subunit 3
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
LTF lactotransferrin
MAPK13 mitogen-activated protein kinase 13
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MRPL12 mitochondrial ribosomal protein L12
MRPL23 mitochondrial ribosomal protein L23
MRPS30 mitochondrial ribosomal protein S30
MXRA7 matrix-remodelling associated 7
NGRN neugrin, neurite outgrowth associated
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
NUP98 nucleoporin 98kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PCCB propionyl CoA carboxylase, beta polypeptide
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SEPT9 septin 9
SHCBP1 SHC SH2-domain binding protein 1
SORBS3 sorbin and SH3 domain containing 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SRPRB signal recognition particle receptor, B subunit
STEAP1 six transmembrane epithelial antigen of the prostate 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM109 transmembrane protein 109
TRIP6 thyroid hormone receptor interactor 6
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZNF512B zinc finger protein 512B