BRD-K09499853_KU 0060648 trihydrochloride_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

405 genes differentially expressed following the BRD-K09499853_KU 0060648 trihydrochloride_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
AHNAK2 AHNAK nucleoprotein 2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATM ATM serine/threonine kinase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN3 calpain 3, (p94)
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CES2 carboxylesterase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLIC3 chloride intracellular channel 3
CPQ carboxypeptidase Q
CREG1 cellular repressor of E1A-stimulated genes 1
CST6 cystatin E/M
CYB5R1 cytochrome b5 reductase 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DMPK dystrophia myotonica-protein kinase
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F11R F11 receptor
FAM50A family with sequence similarity 50, member A
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FYCO1 FYVE and coiled-coil domain containing 1
GAS6 growth arrest-specific 6
GDI1 GDP dissociation inhibitor 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSDMB gasdermin B
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IGF2R insulin-like growth factor 2 receptor
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KIAA1033 KIAA1033
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
ORM1 orosomucoid 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PCYOX1 prenylcysteine oxidase 1
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PLCB4 phospholipase C, beta 4
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB5B RAB5B, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRAGC Ras-related GTP binding C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
STK38 serine/threonine kinase 38
THBS1 thrombospondin 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BATF3 basic leucine zipper transcription factor, ATF-like 3
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BLVRA biliverdin reductase A
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF112 chromosome 1 open reading frame 112
CALD1 caldesmon 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
COCH cochlin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EED embryonic ectoderm development
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEMIN2 gem (nuclear organelle) associated protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
ICAM3 intercellular adhesion molecule 3
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LHX2 LIM homeobox 2
LMNB1 lamin B1
LPL lipoprotein lipase
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAK16 MAK16 homolog (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MICALL1 MICAL-like 1
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MOK MOK protein kinase
MRPL3 mitochondrial ribosomal protein L3
MRPS30 mitochondrial ribosomal protein S30
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP107 nucleoporin 107kDa
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
NXT1 nuclear transport factor 2-like export factor 1
OIP5 Opa interacting protein 5
P3H2 prolyl 3-hydroxylase 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCOLCE procollagen C-endopeptidase enhancer
PDGFA platelet-derived growth factor alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PODXL podocalyxin-like
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMC3IP PSMC3 interacting protein
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RASIP1 Ras interacting protein 1
RBM14 RNA binding motif protein 14
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPP25 ribonuclease P/MRP 25kDa subunit
RPP30 ribonuclease P/MRP 30kDa subunit
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SDF2L1 stromal cell-derived factor 2-like 1
SHCBP1 SHC SH2-domain binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SMC2 structural maintenance of chromosomes 2
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORBS3 sorbin and SH3 domain containing 3
SPAG5 sperm associated antigen 5
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRI sorcin
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAM transcription factor A, mitochondrial
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UCK2 uridine-cytidine kinase 2
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein