BRD-K08996725_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K08996725_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA6 annexin A6
ARMT1 acidic residue methyltransferase 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
BTN3A2 butyrophilin, subfamily 3, member A2
C1S complement component 1, s subcomponent
CAPN3 calpain 3, (p94)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L2 chitinase 3-like 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CYBA cytochrome b-245, alpha polypeptide
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL2 ELOVL fatty acid elongase 2
EPCAM epithelial cell adhesion molecule
FOLR1 folate receptor 1 (adult)
GSTM3 glutathione S-transferase mu 3 (brain)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HLTF helicase-like transcription factor
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFITM1 interferon induced transmembrane protein 1
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IQGAP2 IQ motif containing GTPase activating protein 2
JARID2 jumonji, AT rich interactive domain 2
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LTBP3 latent transforming growth factor beta binding protein 3
MEGF9 multiple EGF-like-domains 9
MICB MHC class I polypeptide-related sequence B
NPC2 Niemann-Pick disease, type C2
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PENK proenkephalin
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTCH1 patched 1
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RNF14 ring finger protein 14
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TSPAN3 tetraspanin 3

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AIM1 absent in melanoma 1
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1QA complement component 1, q subcomponent, A chain
C3ORF14 chromosome 3 open reading frame 14
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
GPC4 glypican 4
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
IPO13 importin 13
KRT15 keratin 15, type I
KRT81 keratin 81, type II
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
MTSS1 metastasis suppressor 1
NARFL nuclear prelamin A recognition factor-like
NDNF neuron-derived neurotrophic factor
NEFL neurofilament, light polypeptide
NIT1 nitrilase 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NVL nuclear VCP-like
OSBPL10 oxysterol binding protein-like 10
PAPD7 PAP associated domain containing 7
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRUNE2 prune homolog 2 (Drosophila)
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
RTN2 reticulon 2
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX7 sorting nexin 7
STS steroid sulfatase (microsomal), isozyme S
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395