BRD-K08799216_pelitinib_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

197 genes differentially expressed following the BRD-K08799216_pelitinib_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AHNAK AHNAK nucleoprotein
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
CA11 carbonic anhydrase XI
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CSAD cysteine sulfinic acid decarboxylase
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAXDC2 fatty acid hydroxylase domain containing 2
FNBP1L formin binding protein 1-like
FSD1 fibronectin type III and SPRY domain containing 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXC6 homeobox C6
KIAA1324 KIAA1324
KLHDC2 kelch domain containing 2
LAMP2 lysosomal-associated membrane protein 2
LOXL2 lysyl oxidase-like 2
MEIS1 Meis homeobox 1
MLPH melanophilin
MUC1 mucin 1, cell surface associated
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OBSL1 obscurin-like 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PRKCQ protein kinase C, theta
PRSS8 protease, serine, 8
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SLC38A1 solute carrier family 38, member 1
SPDEF SAM pointed domain containing ETS transcription factor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYT17 synaptotagmin XVII
TFPI2 tissue factor pathway inhibitor 2
TOM1L1 target of myb1 (chicken)-like 1
TRAF5 TNF receptor-associated factor 5
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACTB actin, beta
AEBP1 AE binding protein 1
AKR1C2 aldo-keto reductase family 1, member C2
ANOS1 anosmin 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CD48 CD48 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
COCH cochlin
CXCL10 chemokine (C-X-C motif) ligand 10
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUOX2 dual oxidase 2
ELN elastin
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXM1 forkhead box M1
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL13RA2 interleukin 13 receptor, alpha 2
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LIPG lipase, endothelial
LMNB1 lamin B1
LTF lactotransferrin
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
PBK PDZ binding kinase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RRM2 ribonucleotide reductase M2
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)