BRD-K08799216_pelitinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K08799216_pelitinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG6 adhesion G protein-coupled receptor G6
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATP11B ATPase, class VI, type 11B
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CCDC69 coiled-coil domain containing 69
CCDC92 coiled-coil domain containing 92
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CTSE cathepsin E
CTSH cathepsin H
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GYPC glycophorin C (Gerbich blood group)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IFI6 interferon, alpha-inducible protein 6
JCHAIN joining chain of multimeric IgA and IgM
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
MAOA monoamine oxidase A
MICALL1 MICAL-like 1
MLPH melanophilin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MXRA7 matrix-remodelling associated 7
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK10 serine/threonine kinase 10
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
CA2 carbonic anhydrase II
CD24 CD24 molecule
CLU clusterin
CP ceruloplasmin (ferroxidase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EREG epiregulin
LOX lysyl oxidase
MAP7 microtubule-associated protein 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1M metallothionein 1M
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PTHLH parathyroid hormone-like hormone
SEPP1 selenoprotein P, plasma, 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)