BRD-K08799216_pelitinib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K08799216_pelitinib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
METTL7A methyltransferase like 7A
NRCAM neuronal cell adhesion molecule
PDZK1 PDZ domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RGS2 regulator of G-protein signaling 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
AREG amphiregulin
CCL20 chemokine (C-C motif) ligand 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CSNK1E casein kinase 1, epsilon
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCN decorin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HOXB2 homeobox B2
IER3 immediate early response 3
JUN jun proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LAMP3 lysosomal-associated membrane protein 3
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MRPS2 mitochondrial ribosomal protein S2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
OSMR oncostatin M receptor
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PROM1 prominin 1
RGCC regulator of cell cycle
RPIA ribose 5-phosphate isomerase A
RPL10 ribosomal protein L10
SCGB2A1 secretoglobin, family 2A, member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY4 sprouty homolog 4 (Drosophila)
STX1A syntaxin 1A (brain)
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TRIB2 tribbles pseudokinase 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1