BRD-K08799216_pelitinib_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

285 genes differentially expressed following the BRD-K08799216_pelitinib_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOD apolipoprotein D
APOE apolipoprotein E
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BLVRB biliverdin reductase B
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
CRYAB crystallin, alpha B
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DNASE2 deoxyribonuclease II, lysosomal
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM65B family with sequence similarity 65, member B
FBLN1 fibulin 1
FBLN2 fibulin 2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSE1 Gse1 coiled-coil protein
GSTA1 glutathione S-transferase alpha 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HBD hemoglobin, delta
HCAR3 hydroxycarboxylic acid receptor 3
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT8 keratin 8, type II
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LTBP1 latent transforming growth factor beta binding protein 1
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NOTCH3 notch 3
NPEPL1 aminopeptidase-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPL periplakin
PRSS8 protease, serine, 8
PSAP prosaposin
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RRAGD Ras-related GTP binding D
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD2 superoxide dismutase 2, mitochondrial
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TF transferrin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TYMP thymidine phosphorylase
VAV3 vav 3 guanine nucleotide exchange factor
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
ETV5 ets variant 5
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO21 F-box protein 21
FEN1 flap structure-specific endonuclease 1
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLK6 kallikrein-related peptidase 6
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NRG1 neuregulin 1
NT5E 5'-nucleotidase, ecto (CD73)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PRSS3 protease, serine, 3
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VIM vimentin
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZWINT ZW10 interacting kinetochore protein