BRD-K08799216_pelitinib_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-K08799216_pelitinib_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACSL5 acyl-CoA synthetase long-chain family member 5
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOL1 apolipoprotein L, 1
ASPN asporin
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL3A1 collagen, type III, alpha 1
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FAM65B family with sequence similarity 65, member B
FBLN1 fibulin 1
FGF9 fibroblast growth factor 9
FGG fibrinogen gamma chain
GAA glucosidase, alpha; acid
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSN gelsolin
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
MAOA monoamine oxidase A
MATN2 matrilin 2
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PSAP prosaposin
PTN pleiotrophin
PVALB parvalbumin
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RSRP1 arginine/serine-rich protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
STS steroid sulfatase (microsomal), isozyme S
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYBU syntabulin (syntaxin-interacting)
SYNE2 spectrin repeat containing, nuclear envelope 2
TMPRSS4 transmembrane protease, serine 4
TRAM2 translocation associated membrane protein 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
UBXN4 UBX domain protein 4
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
AK1 adenylate kinase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ETV5 ets variant 5
EXOSC9 exosome component 9
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAMLD1 mastermind-like domain containing 1
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN4 tetraspanin 4
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VIM vimentin
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein