BRD-K08799216_pelitinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K08799216_pelitinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP10B ATPase, class V, type 10B
BTN3A2 butyrophilin, subfamily 3, member A2
CBS cystathionine-beta-synthase
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
CTSS cathepsin S
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GPX2 glutathione peroxidase 2
HAMP hepcidin antimicrobial peptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP1 insulin-like growth factor binding protein 1
IGKC immunoglobulin kappa constant
ITGA6 integrin, alpha 6
LIMCH1 LIM and calponin homology domains 1
MAOA monoamine oxidase A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH10 myosin, heavy chain 10, non-muscle
MYO10 myosin X
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL9 oxysterol binding protein-like 9
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE10A phosphodiesterase 10A
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX10 SRY (sex determining region Y)-box 10
SPINK1 serine peptidase inhibitor, Kazal type 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TES testin LIM domain protein
TPD52 tumor protein D52
TRAF5 TNF receptor-associated factor 5
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
BID BH3 interacting domain death agonist
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD93 CD93 molecule
CDC42 cell division cycle 42
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CYR61 cysteine-rich, angiogenic inducer, 61
DPYSL2 dihydropyrimidinase-like 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF13 fibroblast growth factor 13
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GSN gelsolin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP6 insulin-like growth factor binding protein 6
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX3-1 NK3 homeobox 1
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TMEM97 transmembrane protein 97
TUBA1A tubulin, alpha 1a