BRD-K08640512_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K08640512_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CKAP4 cytoskeleton-associated protein 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EML3 echinoderm microtubule associated protein like 3
ENO2 enolase 2 (gamma, neuronal)
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB7 homeobox B7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6R interleukin 6 receptor
KLK10 kallikrein-related peptidase 10
LEF1 lymphoid enhancer-binding factor 1
LINC00341 long intergenic non-protein coding RNA 341
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
MUC5B mucin 5B, oligomeric mucus/gel-forming
NKX3-1 NK3 homeobox 1
PLK2 polo-like kinase 2
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
RCAN1 regulator of calcineurin 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPEN spen family transcriptional repressor
SRSF6 serine/arginine-rich splicing factor 6
STXBP1 syntaxin binding protein 1
TBL1X transducin (beta)-like 1X-linked
TFF3 trefoil factor 3 (intestinal)
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FBXL12 F-box and leucine-rich repeat protein 12
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
GPM6B glycoprotein M6B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KRT18 keratin 18, type I
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MT1E metallothionein 1E
MT1F metallothionein 1F
NEBL nebulette
NPY1R neuropeptide Y receptor Y1
OLFM4 olfactomedin 4
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPOX protoporphyrinogen oxidase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGCC regulator of cell cycle
RNF167 ring finger protein 167
SCG5 secretogranin V
SDC4 syndecan 4
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC38A1 solute carrier family 38, member 1
STC1 stanniocalcin 1
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
THBS1 thrombospondin 1
TMEM45A transmembrane protein 45A
TRIM2 tripartite motif containing 2
TUBB2B tubulin, beta 2B class IIb
VNN1 vanin 1