BRD-K08547377_Irinotecan hydrochloride trihydrate_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K08547377_Irinotecan hydrochloride trihydrate_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAD8 acyl-CoA dehydrogenase family, member 8
ADGRF5 adhesion G protein-coupled receptor F5
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
BEX4 brain expressed, X-linked 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
KRT15 keratin 15, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
MMP12 matrix metallopeptidase 12
PERP PERP, TP53 apoptosis effector
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SESN1 sestrin 1
SULF1 sulfatase 1
TMEM45A transmembrane protein 45A
TRIM22 tripartite motif containing 22

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ANXA7 annexin A7
APOD apolipoprotein D
AURKA aurora kinase A
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CENPA centromere protein A
COPS7A COP9 signalosome subunit 7A
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
GRWD1 glutamate-rich WD repeat containing 1
KIF20A kinesin family member 20A
LBR lamin B receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MITF microphthalmia-associated transcription factor
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PARP2 poly (ADP-ribose) polymerase 2
PFN2 profilin 2
PLK1 polo-like kinase 1
PROM1 prominin 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SKP1 S-phase kinase-associated protein 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
ZMYM2 zinc finger, MYM-type 2