BRD-K08547377_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K08547377_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLC Charcot-Leyden crystal galectin
CORO1A coronin, actin binding protein, 1A
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ETHE1 ethylmalonic encephalopathy 1
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FDXR ferredoxin reductase
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GRN granulin
GSN gelsolin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGL immunoglobulin lambda locus
IRF7 interferon regulatory factor 7
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT7 keratin 7, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LOC100505650 uncharacterized LOC100505650
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MVP major vault protein
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
OBSL1 obscurin-like 1
PDGFA platelet-derived growth factor alpha polypeptide
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLXNB2 plexin B2
PNKP polynucleotide kinase 3'-phosphatase
PYCARD PYD and CARD domain containing
RAP1GAP2 RAP1 GTPase activating protein 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RTN2 reticulon 2
SDC4 syndecan 4
SH3YL1 SH3 and SYLF domain containing 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRGN serglycin
SST somatostatin
STON1 stonin 1
SULF1 sulfatase 1
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TP53TG1 TP53 target 1 (non-protein coding)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC6 cell division cycle 6
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHD1 chromodomain helicase DNA binding protein 1
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CP ceruloplasmin (ferroxidase)
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
GABPB1 GA binding protein transcription factor, beta subunit 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOMER2 homer scaffolding protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IER3 immediate early response 3
IRX5 iroquois homeobox 5
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCOLN1 mucolipin 1
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1X metallothionein 1X
NCAPG non-SMC condensin I complex, subunit G
NMU neuromedin U
NRIP1 nuclear receptor interacting protein 1
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PER2 period circadian clock 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
RFC3 replication factor C (activator 1) 3, 38kDa
RHOBTB3 Rho-related BTB domain containing 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
STK39 serine threonine kinase 39
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TTK TTK protein kinase
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
ZWILCH zwilch kinetochore protein