BRD-K08547377_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K08547377_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CCDC92 coiled-coil domain containing 92
CCND1 cyclin D1
CCND2 cyclin D2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN1 chimerin 1
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNASE1L1 deoxyribonuclease I-like 1
DUSP3 dual specificity phosphatase 3
EPHA2 EPH receptor A2
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
EYA1 EYA transcriptional coactivator and phosphatase 1
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GRB7 growth factor receptor-bound protein 7
GRN granulin
IER5 immediate early response 5
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLF5 Kruppel-like factor 5 (intestinal)
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LMNA lamin A/C
LRP10 low density lipoprotein receptor-related protein 10
LTBP3 latent transforming growth factor beta binding protein 3
LY75 lymphocyte antigen 75
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NPEPL1 aminopeptidase-like 1
PDGFA platelet-derived growth factor alpha polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PGAP3 post-GPI attachment to proteins 3
PI3 peptidase inhibitor 3, skin-derived
PLXNB2 plexin B2
PPL periplakin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RASA4 RAS p21 protein activator 4
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS27L ribosomal protein S27-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSL1D1 ribosomal L1 domain containing 1
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TDO2 tryptophan 2,3-dioxygenase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TP63 tumor protein p63
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMD1 adenosylmethionine decarboxylase 1
AUTS2 autism susceptibility candidate 2
CCNB2 cyclin B2
CCNE2 cyclin E2
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COG7 component of oligomeric golgi complex 7
CRYZ crystallin, zeta (quinone reductase)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FBN1 fibrillin 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA6 GATA binding protein 6
HIST1H2BK histone cluster 1, H2bk
IGL immunoglobulin lambda locus
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LDB2 LIM domain binding 2
LTF lactotransferrin
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MORF4L2 mortality factor 4 like 2
MXRA5 matrix-remodelling associated 5
NAV3 neuron navigator 3
NBN nibrin
NTS neurotensin
OLFM1 olfactomedin 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
RAP1GAP RAP1 GTPase activating protein
RNF167 ring finger protein 167
RPIA ribose 5-phosphate isomerase A
SPP1 secreted phosphoprotein 1
STX1A syntaxin 1A (brain)
TARP TCR gamma alternate reading frame protein
TBCB tubulin folding cofactor B
TCF4 transcription factor 4
THBS1 thrombospondin 1
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
VCAN versican
WFDC2 WAP four-disulfide core domain 2