BRD-K08502430_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K08502430_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCT2 chaperonin containing TCP1, subunit 2 (beta)
DDIT4 DNA-damage-inducible transcript 4
ENO2 enolase 2 (gamma, neuronal)
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
PRNP prion protein
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TSPAN13 tetraspanin 13
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHL1 cell adhesion molecule L1-like
CLEC2B C-type lectin domain family 2, member B
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCN decorin
DOK5 docking protein 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPRC5B G protein-coupled receptor, class C, group 5, member B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LPAR6 lysophosphatidic acid receptor 6
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NMU neuromedin U
PGLS 6-phosphogluconolactonase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TBC1D31 TBC1 domain family, member 31
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa