BRD-K08502430_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K08502430_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CD52 CD52 molecule
CD9 CD9 molecule
CPA3 carboxypeptidase A3 (mast cell)
CTBP2 C-terminal binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT4 DNA-damage-inducible transcript 4
DPT dermatopontin
EREG epiregulin
F11R F11 receptor
FAM129A family with sequence similarity 129, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR1 fibroblast growth factor receptor 1
GAL galanin/GMAP prepropeptide
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
JAG1 jagged 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MX1 MX dynamin-like GTPase 1
NUPL1 nucleoporin like 1
PEA15 phosphoprotein enriched in astrocytes 15
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PWP1 PWP1 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOX2 acyl-CoA oxidase 2, branched chain
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA6 annexin A6
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CRYAB crystallin, alpha B
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCXR dicarbonyl/L-xylulose reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFNA1 ephrin-A1
GPX3 glutathione peroxidase 3
HSPA1A heat shock 70kDa protein 1A
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRT19 keratin 19, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
PLK1 polo-like kinase 1
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
REEP1 receptor accessory protein 1
RHOBTB3 Rho-related BTB domain containing 3
RPL37A ribosomal protein L37a
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SORBS3 sorbin and SH3 domain containing 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TF transferrin
TP53 tumor protein p53
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28