BRD-K08448573_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K08448573_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADIRF adipogenesis regulatory factor
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EPRS glutamyl-prolyl-tRNA synthetase
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IFI27 interferon, alpha-inducible protein 27
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
MAOB monoamine oxidase B
MARS methionyl-tRNA synthetase
MT1E metallothionein 1E
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RGS2 regulator of G-protein signaling 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDF2L1 stromal cell-derived factor 2-like 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TCTA T-cell leukemia translocation altered
TES testin LIM domain protein
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
CLU clusterin
COLEC12 collectin sub-family member 12
DEFB1 defensin, beta 1
EPHA3 EPH receptor A3
GJA1 gap junction protein, alpha 1, 43kDa
GPC3 glypican 3
GPX3 glutathione peroxidase 3
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
LSM1 LSM1, U6 small nuclear RNA associated
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
NID1 nidogen 1
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SPRR3 small proline-rich protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1