BRD-K08438429_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K08438429_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COL11A1 collagen, type XI, alpha 1
CTBP2 C-terminal binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GREM1 gremlin 1, DAN family BMP antagonist
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
INHBA inhibin, beta A
KLK5 kallikrein-related peptidase 5
MAP7 microtubule-associated protein 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZB1 marginal zone B and B1 cell-specific protein
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
RYBP RING1 and YY1 binding protein
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD1 SMAD family member 1
SNAI2 snail family zinc finger 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRRM2 serine/arginine repetitive matrix 2
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRL2 adhesion G protein-coupled receptor L2
AKAP7 A kinase (PRKA) anchor protein 7
B3GNT1
C4BPA complement component 4 binding protein, alpha
CFI complement factor I
CIB1 calcium and integrin binding 1 (calmyrin)
CTSC cathepsin C
DERA deoxyribose-phosphate aldolase (putative)
DKK1 dickkopf WNT signaling pathway inhibitor 1
FGG fibrinogen gamma chain
GPX3 glutathione peroxidase 3
HSPA8 heat shock 70kDa protein 8
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRN3 leucine rich repeat neuronal 3
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MMD monocyte to macrophage differentiation-associated
MXRA7 matrix-remodelling associated 7
MYD88 myeloid differentiation primary response 88
MYO1B myosin IB
NFIB nuclear factor I/B
PROS1 protein S (alpha)
RBP4 retinol binding protein 4, plasma
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPS27L ribosomal protein S27-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPC surfactant protein C
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYBU syntabulin (syntaxin-interacting)
TFPI2 tissue factor pathway inhibitor 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB tubulin, beta class I
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WSB2 WD repeat and SOCS box containing 2