BRD-K08417745_SID 26681509_SKMEL28_6.0_h_88.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K08417745_SID 26681509_SKMEL28_6.0_h_88.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C3ORF14 chromosome 3 open reading frame 14
CALML3 calmodulin-like 3
CAST calpastatin
CD38 CD38 molecule
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLGN calmegin
CNPY3 canopy FGF signaling regulator 3
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IFRD1 interferon-related developmental regulator 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO13 importin 13
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
LYPD3 LY6/PLAUR domain containing 3
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEBL nebulette
NOX4 NADPH oxidase 4
NPTX2 neuronal pentraxin II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDC1 syndecan 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SESN1 sestrin 1
SFTPC surfactant protein C
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D31 TBC1 domain family, member 31
TGFA transforming growth factor, alpha
TLR4 toll-like receptor 4
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
XPOT exportin, tRNA
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AURKA aurora kinase A
CAPN3 calpain 3, (p94)
CCNA2 cyclin A2
CCNB1 cyclin B1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CKB creatine kinase, brain
COL6A1 collagen, type VI, alpha 1
COL9A3 collagen, type IX, alpha 3
CYCS cytochrome c, somatic
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
ECI2 enoyl-CoA delta isomerase 2
ERAP2 endoplasmic reticulum aminopeptidase 2
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM57A family with sequence similarity 57, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITM2A integral membrane protein 2A
LBR lamin B receptor
MATN2 matrilin 2
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
MXRA7 matrix-remodelling associated 7
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OXA1L oxidase (cytochrome c) assembly 1-like
PDZK1 PDZ domain containing 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKP2 plakophilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
SATB1 SATB homeobox 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SRSF6 serine/arginine-rich splicing factor 6
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP6 syntaxin binding protein 6 (amisyn)
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
UBE2S ubiquitin-conjugating enzyme E2S
WBP5 WW domain binding protein 5
WFDC2 WAP four-disulfide core domain 2