BRD-K08417745_SID 26681509_MCF7_24.0_h_88.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K08417745_SID 26681509_MCF7_24.0_h_88.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP1 aquaporin 1 (Colton blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
CXCL11 chemokine (C-X-C motif) ligand 11
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DPP4 dipeptidyl-peptidase 4
EPAS1 endothelial PAS domain protein 1
FAM69A family with sequence similarity 69, member A
FGG fibrinogen gamma chain
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GPX2 glutathione peroxidase 2
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
KRT7 keratin 7, type II
LBH limb bud and heart development
LITAF lipopolysaccharide-induced TNF factor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PIR pirin (iron-binding nuclear protein)
RAP1GAP RAP1 GTPase activating protein
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RTN1 reticulon 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
TACC2 transforming, acidic coiled-coil containing protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
TRDV3 T cell receptor delta variable 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)

decreased expression

Symbol Name
ASRGL1 asparaginase like 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CENPU centromere protein U
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EVL Enah/Vasp-like
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HLTF helicase-like transcription factor
HMMR hyaluronan-mediated motility receptor (RHAMM)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LMNB1 lamin B1
LTF lactotransferrin
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MTERF3 mitochondrial transcription termination factor 3
MUC1 mucin 1, cell surface associated
NOP56 NOP56 ribonucleoprotein
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTTG1 pituitary tumor-transforming 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STMN1 stathmin 1
TPX2 TPX2, microtubule-associated
TRAPPC4 trafficking protein particle complex 4
TUBA1A tubulin, alpha 1a
TYMS thymidylate synthetase
VCAN versican
ZWINT ZW10 interacting kinetochore protein