BRD-K08417745_SID 26681509_HCT116_6.0_h_88.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K08417745_SID 26681509_HCT116_6.0_h_88.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BRCA1 breast cancer 1, early onset
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR2 early growth response 2
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGKV4-1 immunoglobulin kappa variable 4-1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF14 kinesin family member 14
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LGALS8 lectin, galactoside-binding, soluble, 8
LMCD1 LIM and cysteine-rich domains 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PPIB peptidylprolyl isomerase B (cyclophilin B)
RCAN1 regulator of calcineurin 1
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SNX11 sorting nexin 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
TAGLN transgelin
TESC tescalcin
TGM4 transglutaminase 4
TM4SF1 transmembrane 4 L six family member 1
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR7 WD repeat domain 7
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
BAD BCL2-associated agonist of cell death
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CHERP calcium homeostasis endoplasmic reticulum protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
COL4A5 collagen, type IV, alpha 5
CXCL10 chemokine (C-X-C motif) ligand 10
DEFB1 defensin, beta 1
FAT1 FAT atypical cadherin 1
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
GAL galanin/GMAP prepropeptide
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGA2 high mobility group AT-hook 2
IGL immunoglobulin lambda locus
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
NRIP1 nuclear receptor interacting protein 1
NVL nuclear VCP-like
REEP1 receptor accessory protein 1
RERE arginine-glutamic acid dipeptide (RE) repeats
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TLE4 transducin-like enhancer of split 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18