BRD-K08417745_SID 26681509_A549_6.0_h_88.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K08417745_SID 26681509_A549_6.0_h_88.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
AGTR1 angiotensin II receptor, type 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CST3 cystatin C
CTBS chitobiase, di-N-acetyl-
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM129A family with sequence similarity 129, member A
FBN1 fibrillin 1
FGF13 fibroblast growth factor 13
FGL2 fibrinogen-like 2
FHL2 four and a half LIM domains 2
FXYD3 FXYD domain containing ion transport regulator 3
GARS glycyl-tRNA synthetase
GCH1 GTP cyclohydrolase 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IL6 interleukin 6
ITM2A integral membrane protein 2A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOCOS molybdenum cofactor sulfurase
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
SOBP sine oculis binding protein homolog (Drosophila)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC2 stanniocalcin 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR2 toll-like receptor 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AURKA aurora kinase A
C14ORF169 chromosome 14 open reading frame 169
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GJA1 gap junction protein, alpha 1, 43kDa
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KIAA0232 KIAA0232
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LYZ lysozyme
MEIS1 Meis homeobox 1
MXRA7 matrix-remodelling associated 7
PAEP progestagen-associated endometrial protein
PNISR PNN-interacting serine/arginine-rich protein
RGS1 regulator of G-protein signaling 1
SOX4 SRY (sex determining region Y)-box 4
SRSF2 serine/arginine-rich splicing factor 2
TXNDC9 thioredoxin domain containing 9
UPK1B uroplakin 1B
VWA5A von Willebrand factor A domain containing 5A
WWC1 WW and C2 domain containing 1
ZBTB1 zinc finger and BTB domain containing 1