BRD-K08417745_SID 26681509_A375_24.0_h_88.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K08417745_SID 26681509_A375_24.0_h_88.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF6 activating transcription factor 6
CA12 carbonic anhydrase XII
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CKAP4 cytoskeleton-associated protein 4
CRABP2 cellular retinoic acid binding protein 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLGA4 golgin A4
GSDMB gasdermin B
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
KRT81 keratin 81, type II
LTBP1 latent transforming growth factor beta binding protein 1
MANF mesencephalic astrocyte-derived neurotrophic factor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA6 protein disulfide isomerase family A, member 6
PPIB peptidylprolyl isomerase B (cyclophilin B)
PYCR1 pyrroline-5-carboxylate reductase 1
S100A8 S100 calcium binding protein A8
SDF2L1 stromal cell-derived factor 2-like 1
SEC63 SEC63 homolog (S. cerevisiae)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35B1 solute carrier family 35, member B1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM45A transmembrane protein 45A
TPBG trophoblast glycoprotein
TRAM1 translocation associated membrane protein 1
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADD3 adducin 3 (gamma)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHCY adenosylhomocysteinase
ALCAM activated leukocyte cell adhesion molecule
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BIRC5 baculoviral IAP repeat containing 5
CALCA calcitonin-related polypeptide alpha
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNF cyclin F
CCNG1 cyclin G1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DUT deoxyuridine triphosphatase
EDNRB endothelin receptor type B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM162A family with sequence similarity 162, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTP1 glutathione S-transferase pi 1
GTF2H5 general transcription factor IIH, polypeptide 5
HADH hydroxyacyl-CoA dehydrogenase
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGN3 high mobility group nucleosomal binding domain 3
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NLGN4X neuroligin 4, X-linked
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QDPR quinoid dihydropteridine reductase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
S100A4 S100 calcium binding protein A4
SEPP1 selenoprotein P, plasma, 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SOX2 SRY (sex determining region Y)-box 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WWTR1 WW domain containing transcription regulator 1