BRD-K08316444_-666_MCF7_24.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K08316444_-666_MCF7_24.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BRD4 bromodomain containing 4
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CD40 CD40 molecule, TNF receptor superfamily member 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLASRP CLK4-associating serine/arginine rich protein
COL18A1 collagen, type XVIII, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
EMP3 epithelial membrane protein 3
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
FSCN1 fascin actin-bundling protein 1
FZD5 frizzled class receptor 5
GAL galanin/GMAP prepropeptide
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLX H2.0-like homeobox
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPG2 heparan sulfate proteoglycan 2
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG1 jagged 1
KRT17 keratin 17, type I
KRT81 keratin 81, type II
MAP1B microtubule-associated protein 1B
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICALL2 MICAL-like 2
MTSS1 metastasis suppressor 1
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLXNB2 plexin B2
PYGB phosphorylase, glycogen; brain
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
SEC62 SEC62 homolog (S. cerevisiae)
SERINC5 serine incorporator 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STAR steroidogenic acute regulatory protein
STK26 serine/threonine protein kinase 26
TCF3 transcription factor 3
TGFA transforming growth factor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZYX zyxin

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
CCNE2 cyclin E2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CFI complement factor I
CGRRF1 cell growth regulator with ring finger domain 1
CPNE3 copine III
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GBE1 glucan (1,4-alpha-), branching enzyme 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUD1 glutamate dehydrogenase 1
GLUL glutamate-ammonia ligase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IL17RB interleukin 17 receptor B
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
KRT19 keratin 19, type I
MAP2K6 mitogen-activated protein kinase kinase 6
MCM6 minichromosome maintenance complex component 6
MSH6 mutS homolog 6
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NET1 neuroepithelial cell transforming 1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PPIF peptidylprolyl isomerase F
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RAB31 RAB31, member RAS oncogene family
RBBP4 retinoblastoma binding protein 4
RFC2 replication factor C (activator 1) 2, 40kDa
RGS4 regulator of G-protein signaling 4
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELT selenoprotein T
SMC2 structural maintenance of chromosomes 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SSR1 signal sequence receptor, alpha
TFPI2 tissue factor pathway inhibitor 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZWINT ZW10 interacting kinetochore protein