BRD-K08307026_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

255 genes differentially expressed following the BRD-K08307026_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL11A1 collagen, type XI, alpha 1
COL9A2 collagen, type IX, alpha 2
CTH cystathionine gamma-lyase
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GATA6 GATA binding protein 6
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GPI glucose-6-phosphate isomerase
GPR137B G protein-coupled receptor 137B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
INSR insulin receptor
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
LOX lysyl oxidase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFSD10 major facilitator superfamily domain containing 10
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP12 matrix metallopeptidase 12
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRN1 neuritin 1
OPN3 opsin 3
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POPDC3 popeye domain containing 3
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PTPRR protein tyrosine phosphatase, receptor type, R
RHOB ras homolog family member B
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SPAG4 sperm associated antigen 4
SST somatostatin
STC1 stanniocalcin 1
TBX3 T-box 3
TES testin LIM domain protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNS3 tensin 3
TRIO trio Rho guanine nucleotide exchange factor
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF117 zinc finger protein 117
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANPEP alanyl (membrane) aminopeptidase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG3 autophagy related 3
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
C7 complement component 7
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DENND2D DENN/MADD domain containing 2D
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECT2 epithelial cell transforming 2
ELOVL6 ELOVL fatty acid elongase 6
EML3 echinoderm microtubule associated protein like 3
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM64A family with sequence similarity 64, member A
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS2L1 growth arrest-specific 2 like 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP4 insulin-like growth factor binding protein 4
IPO4 importin 4
IRF8 interferon regulatory factor 8
KIAA0391 KIAA0391
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MAB21L2 mab-21-like 2 (C. elegans)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED1 melanoma antigen family D1
MCM2 minichromosome maintenance complex component 2
MKI67 marker of proliferation Ki-67
MLEC malectin
MRPL12 mitochondrial ribosomal protein L12
NBN nibrin
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TSPAN4 tetraspanin 4
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein