BRD-K08109215_I-BET_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K08109215_I-BET_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CLCN3 chloride channel, voltage-sensitive 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRN granulin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
IGHM immunoglobulin heavy constant mu
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
LEFTY1 left-right determination factor 1
MALT1 MALT1 paracaspase
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MOAP1 modulator of apoptosis 1
MXRA7 matrix-remodelling associated 7
NDNF neuron-derived neurotrophic factor
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCDH9 protocadherin 9
PPA1 pyrophosphatase (inorganic) 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIK1 salt-inducible kinase 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TOB2 transducer of ERBB2, 2
TPD52 tumor protein D52
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC2 apolipoprotein C-II
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCHE butyrylcholinesterase
BID BH3 interacting domain death agonist
C3 complement component 3
CA12 carbonic anhydrase XII
CD200 CD200 molecule
CD99 CD99 molecule
CDC20 cell division cycle 20
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFI complement factor I
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL1A2 collagen, type I, alpha 2
COPS7A COP9 signalosome subunit 7A
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM129A family with sequence similarity 129, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
HMGA2 high mobility group AT-hook 2
HSPB1 heat shock 27kDa protein 1
ICAM3 intercellular adhesion molecule 3
ICT1 immature colon carcinoma transcript 1
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
KYNU kynureninase
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
MAL mal, T-cell differentiation protein
MAPK13 mitogen-activated protein kinase 13
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PDGFD platelet derived growth factor D
PDZK1 PDZ domain containing 1
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
S100A4 S100 calcium binding protein A4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS2 thrombospondin 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TPI1 triosephosphate isomerase 1
VCAN versican