BRD-K08109215_I-BET_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K08109215_I-BET_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTB actin, beta
ADAMDEC1 ADAM-like, decysin 1
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDC42 cell division cycle 42
CHRDL1 chordin-like 1
CLU clusterin
CREG1 cellular repressor of E1A-stimulated genes 1
CYCS cytochrome c, somatic
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
FADS3 fatty acid desaturase 3
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FNTA farnesyltransferase, CAAX box, alpha
FUCA1 fucosidase, alpha-L- 1, tissue
GMPR guanosine monophosphate reductase
HDAC9 histone deacetylase 9
HNMT histamine N-methyltransferase
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
LYPD1 LY6/PLAUR domain containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MTSS1 metastasis suppressor 1
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PNMA1 paraneoplastic Ma antigen 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTN1 reticulon 1
SEPT10 septin 10
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOCS2 suppressor of cytokine signaling 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TMEM176B transmembrane protein 176B
TPM2 tropomyosin 2 (beta)
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ANXA3 annexin A3
ARG1 arginase 1
AUTS2 autism susceptibility candidate 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX4 brain expressed, X-linked 4
C1R complement component 1, r subcomponent
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
EDN1 endothelin 1
EPCAM epithelial cell adhesion molecule
F5 coagulation factor V (proaccelerin, labile factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGG fibrinogen gamma chain
HCAR3 hydroxycarboxylic acid receptor 3
HDDC2 HD domain containing 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
ICAM3 intercellular adhesion molecule 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
MAL mal, T-cell differentiation protein
MGP matrix Gla protein
MTA1 metastasis associated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCOLCE procollagen C-endopeptidase enhancer
PERP PERP, TP53 apoptosis effector
PLK2 polo-like kinase 2
PLVAP plasmalemma vesicle associated protein
PRKCH protein kinase C, eta
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM109 transmembrane protein 109
TMEM45A transmembrane protein 45A
TYMS thymidylate synthetase