BRD-K08109215_I-BET_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K08109215_I-BET_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYBA cytochrome b-245, alpha polypeptide
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
FABP4 fatty acid binding protein 4, adipocyte
FYN FYN proto-oncogene, Src family tyrosine kinase
GATA3 GATA binding protein 3
GOLGA8H golgin A8 family, member H
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOXA5 homeobox A5
ISYNA1 inositol-3-phosphate synthase 1
JAK1 Janus kinase 1
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MYH10 myosin, heavy chain 10, non-muscle
NID2 nidogen 2 (osteonidogen)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORM1 orosomucoid 1
PKP2 plakophilin 2
PLXNC1 plexin C1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REC8 REC8 meiotic recombination protein
RTN3 reticulon 3
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SF1 splicing factor 1
SPON1 spondin 1, extracellular matrix protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP1 syntaxin binding protein 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG1 adhesion G protein-coupled receptor G1
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP13A3 ATPase type 13A3
AUTS2 autism susceptibility candidate 2
C1ORF116 chromosome 1 open reading frame 116
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
COL3A1 collagen, type III, alpha 1
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYTH1 cytohesin 1
EDN1 endothelin 1
EGF epidermal growth factor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
ISG20 interferon stimulated exonuclease gene 20kDa
KRT17 keratin 17, type I
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDLIM5 PDZ and LIM domain 5
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLTP phospholipid transfer protein
PRKCA protein kinase C, alpha
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3YL1 SH3 and SYLF domain containing 1
SLAMF8 SLAM family member 8
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPRY2 sprouty homolog 2 (Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMPRSS2 transmembrane protease, serine 2
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRBC1 T cell receptor beta constant 1
VEGFA vascular endothelial growth factor A
WDR1 WD repeat domain 1
XBP1 X-box binding protein 1
XPO7 exportin 7