BRD-K07762753_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K07762753_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAST calpastatin
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
DPYSL3 dihydropyrimidinase-like 3
ERAP1 endoplasmic reticulum aminopeptidase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
GSPT2 G1 to S phase transition 2
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
INSM1 insulinoma-associated 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA1598
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LRRC15 leucine rich repeat containing 15
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NSG1 neuron specific gene family member 1
OAT ornithine aminotransferase
PAM peptidylglycine alpha-amidating monooxygenase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
SCG2 secretogranin II
SCG5 secretogranin V
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX17 SRY (sex determining region Y)-box 17
SPTSSA serine palmitoyltransferase, small subunit A
SSPN sarcospan
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TOX thymocyte selection-associated high mobility group box
TPGS2 tubulin polyglutamylase complex subunit 2
TPP1 tripeptidyl peptidase I
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP5 WW domain binding protein 5
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADGRG2 adhesion G protein-coupled receptor G2
AK1 adenylate kinase 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD2 C2 calcium-dependent domain containing 2
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CNOT7 CCR4-NOT transcription complex, subunit 7
DCN decorin
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERI2 ERI1 exoribonuclease family member 2
EXOSC2 exosome component 2
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LBR lamin B receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEFH neurofilament, heavy polypeptide
NEFM neurofilament, medium polypeptide
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP37 nucleoporin 37kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTMA prothymosin, alpha
PWP1 PWP1 homolog (S. cerevisiae)
RAD51C RAD51 paralog C
REEP1 receptor accessory protein 1
S100P S100 calcium binding protein P
SDAD1 SDA1 domain containing 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC4 structural maintenance of chromosomes 4
SPDL1 spindle apparatus coiled-coil protein 1
SRSF3 serine/arginine-rich splicing factor 3
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TARP TCR gamma alternate reading frame protein
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TBX2 T-box 2
TEX10 testis expressed 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRAK2 trafficking protein, kinesin binding 2
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VRK1 vaccinia related kinase 1
ZMYM2 zinc finger, MYM-type 2