BRD-K07762753_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K07762753_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACOT7 acyl-CoA thioesterase 7
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BTG3 BTG family, member 3
CA1 carbonic anhydrase I
CCL20 chemokine (C-C motif) ligand 20
CEMIP cell migration inducing protein, hyaluronan binding
CHERP calcium homeostasis endoplasmic reticulum protein
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL11A1 collagen, type XI, alpha 1
CPQ carboxypeptidase Q
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
FCHSD2 FCH and double SH3 domains 2
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMGN4 high mobility group nucleosomal binding domain 4
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IRF8 interferon regulatory factor 8
KCTD12 potassium channel tetramerization domain containing 12
KRT8 keratin 8, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LTBP2 latent transforming growth factor beta binding protein 2
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPT microtubule-associated protein tau
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MSLN mesothelin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
NUAK1 NUAK family, SNF1-like kinase, 1
OPTN optineurin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHGDH phosphoglycerate dehydrogenase
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RIOK3 RIO kinase 3
RSL1D1 ribosomal L1 domain containing 1
RTN1 reticulon 1
SEH1L SEH1-like (S. cerevisiae)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SHB Src homology 2 domain containing adaptor protein B
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
SULF1 sulfatase 1
TRIM22 tripartite motif containing 22
WIPF2 WAS/WASL interacting protein family, member 2
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARHGAP15 Rho GTPase activating protein 15
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCND2 cyclin D2
CD24 CD24 molecule
CD58 CD58 molecule
CDC25B cell division cycle 25B
CENPA centromere protein A
CTSC cathepsin C
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUOX2 dual oxidase 2
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLRT3 fibronectin leucine rich transmembrane protein 3
GOLGA8A golgin A8 family, member A
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGSF3 immunoglobulin superfamily, member 3
IPCEF1 interaction protein for cytohesin exchange factors 1
JADE2 jade family PHD finger 2
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LAMB1 laminin, beta 1
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LRRN3 leucine rich repeat neuronal 3
LUM lumican
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
ODAM odontogenic, ameloblast asssociated
ORC5 origin recognition complex, subunit 5
PLK1 polo-like kinase 1
PLTP phospholipid transfer protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRSS23 protease, serine, 23
RBPMS RNA binding protein with multiple splicing
RPS11 ribosomal protein S11
S100A7 S100 calcium binding protein A7
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
TACC3 transforming, acidic coiled-coil containing protein 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2C ubiquitin-conjugating enzyme E2C
ZWILCH zwilch kinetochore protein